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Miranshah, Pakistan (AFP) - Suspected US spy drones fired missiles early Thursday into a restive Pakistani tribal area on the border with Afghanistan, killing four people, security officials said.

The missiles hit a madrassa, or an Islamic religious school, in a village just outside Miranshah, the main town in North Waziristan, residents and officials said.

"At 2:25 am, two spy drones fired three missiles at the madrassa of Mullah Mansoor. Three people were killed immediately, four were injured and another later expired at hospital," a security official told AFP.